KEYWORDSTwo metal complexes of Ti(IV) were synthesized with newly prepared biologically active ligands. These ligands and their functional groups were carefully designed and selected from well known anticancer drugs. The ligands were prepared by the condensation of a mixture of sulfamethoxazole and the appropriate aldehyde namely, 3,4-dimethoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde. The structure of the ligands and their complexes were confirmed by spectroscopic data i.e. IR, 1 H NMR, electronic and elemental analysis. All compounds were screened for their in vitro anticancer potential using HELA and PC3 cells. All compounds showed limited cytotoxicity and complete cleavage of calf thymus deoxyribonucleic acid (CT-DNA).Titanium DNA studies Sulfamethoxazole Anti-cancer activity Schiff base complexes 3,4-Dimethoxybenzaldehyde
Electrochemical anodic oxidation of a metal anode in an acetone solution of 2,5-diamino-3,4-dicyanothiophene gave the polythiophene metal complexes of Co, Ni, Cu, Zn, Cd, and Sn. Chemical analyses, as well as FTIR and electronic spectral data, are presented to confirm the formulation of the isolated materials. DC electrical conductivity measurements of the polymer complexes were measured in the range 300-500 K in the annealed and 5% doped forms. The products gave electrical conductivity in the semi-conducting region that increased by heat.
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