Background: Helicobacter pylori (H. pylori) infection, a Gram-negative bacterium, causes gastrointestinal symptoms and severe complications after invading gastric mucosa. As the infection could be asymptomatic, it is crucial to enhance knowledge and practices of individuals for prevention of infection. Aim: This study aims to evaluate the efficacy of health literacy sessions regarding helicobacter pylori on students' knowledge and practices. Subject and Methods: A quasi-experimental study examined a convenient sample of 157 students at Damietta University hostels. The data were collected via two tools; tool I: students' characteristics tool and tool II: structured questionnaire (pre-and post-assessment). Results: There was a statistically significant difference in the overall mean scores of students' knowledge and practices between pre-and post-implementation of health literacy sessions (t =15.365, P = 0.000); (t =13.763, P = 0.001) respectively. Moreover, there was a statistically significant positive correlations between students' knowledge and practices through program phases. Conclusions and Recommendations: Screening of H. pylori for early detection should be applicable for most of the population. Furthermore, mass media awareness campaigns should be launched about preventive measures of H. pylori, and annual check-ups should be organized.
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