Background: Alzheimer's disease (AD) is rising health problem with an estimated 6.4% in Saudi Arabia. 80% of dementia cases are caused by AD and usually patients diagnosed at late stages. This study intends to measure the knowledge of Umm Al-Qura University (UQU) undergraduate medical students regarding AD. Methods: Cross-sectional study carried out using an online questionnaire disrupted among medical students. The questionnaire included two sections the first is about demographic data, the second assesses the knowledge related to AD and consisted of 30 true and false items. Results:The total sample number in this study was 332 (54.8% male, while 45.2% were female). The total mean score for this study was 14.12 and most of them (59%) had poor knowledge level regarding AD. Conclusion: This study shows the level of knowledge toward Alzheimer's disease is insufficient amongst medical students at UQU. Meanwhile, a higher academic year is linked to a better level of knowledge. Therefore, focused directed teaching is important to benefit students to develop their knowledge that allows them to do appropriate clinical evaluation by history and physical examination to reach the diagnosis.
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