The ameliorative effects of dietary natural compounds have drawn increasing attention. Dietary antioxidant is considered a common practice adopted in traditional and alternative medicine. The current study was considered to assess the ameliorative effect of grape seed extract on dexamethasone-induced hepatotoxicity in rats. Rats were injected with dexamethasone, (0.1 mg/kg; i.m.), three times per week, for 30 days. The other groups; dexamethasone (0.1 mg/kg) and grape seed extract at a dose of 200 and 400 mg/kg were given orally to rats, respectively. Dexamethasone treatment resulted in a significant elevation in liver function markers activities, lipid profile, and hematological alterations; also, a remarkable increase in hepatic lipid peroxidation marker whereas decreased antioxidant activities in rats. However, administration of grape seed extract resulted in a reversal of dexamethasoneinduced lipid peroxidation, antioxidant enzyme activities, liver function markers and lipid profile, and hematological alterations. Moreover, grape seed extract demonstrated preventive action against dexamethasone-induced histopathological changes in rat liver tissues. In conclusion, grape seed extract exhibited a protective effect in rats against oxidative stress, hyperlipidemia and hematological alterations induced by dexamethasone.
In this study, skin biopsies of two outbreaks of camel pox infection in camels were collected from Belbeis, Sharkeya governorate, Egypt and Al Ain city, Abu Dhabi, United Arab Emirates (UAE) for histopathological diagnosis and polymerase chain reaction (PCR) characterization and identification. Camel pox virus (CPV) reported as a specific viral disease of camel. CPV is highly contagious mainly in calf camels and usually mild in intensity.The mild form, characterized by papular, pustules on the lips, nostrils, cheeks and different parts of skin. CPV usually associated by lymphadenopathy and nasal discharge .This study declared numerous outbreaks of mild pathogenicity for camel pox virus and the causative agent was identified and confirmed as camel pox virus (CPV) by PCR.
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