1‐Oxa‐4‐thiaspiro[4.4]nonan‐2‐one (1a) and/or 1‐oxa‐4‐thiaspiro[4.5] decan‐2‐one (1b) were reacted with aniline and/or p‐chloroaniline to afford the corresponding spirothiazolidinones (2a–d). Reaction of 2a–d with chalcones gave 2‐(α – paracylbenzyl)‐4‐aryl‐1‐thia‐4‐azaspiro[4.4]nonan‐3‐one and 2‐(α‐aracylbenzyl)‐4‐aryl‐1‐thia‐4‐azaspiro[4.5]decan‐3‐one (3a–p) respectively. Compounds 3a–p were reacted with acetic anhydride and perchloric acid to yield the spiropyrano[2,3‐d]thiazol[4]ium perchlorate derivatives 4a–p. The structures of the synthesized compounds were elucidated by elemental and spectroscopic (IR and 1H‐NMR) analysis. All the prepared compounds were tested for their antimicrobial activities in comparison with tetracyclic as a reference compound.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.