:
Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of
ASIC1
and
IL-6
genes and the
IL-6rs-174
and
ASIC1rs 75624685
polymorphisms in the pathogenesis of gastric cancer.
Materials and methods:
Tetra-ARMS PCR was employed to analyze the polymorphism status of the
ASIC1
and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls. We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR.
Results:
Our results showed a significant association between expression of
ASIC1
and elevated risk of gastric cancer (p<0.001).
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