Background: Since June 1999, the majority of cases of Crimean-Congo hemorrhagic fever (CCHF), an arboviral disease, have been reported in the southeast region of Iran. Objectives: The main objective of this study was to investigate CCHF risk perceptions and to identify the factors influencing perceived risk in this area. Patients and Methods:In this cross-sectional study, a total of 400 subjects were randomly recruited through 20 health centers in the city of Zahedan, located in the southeast of Iran. Information was collected by interviewing the respondents using a semi-structured questionnaire. Logistic regression models were used to identify factors associated with a 'high' CCHF perceived risk.Results: Approximately 70% of the respondents reported the CCHF risk to be 'high'. Factors independently associated with a 'high' CCHF perceived risk included; holding a university degree (OR=5.65, 95%CI 2.02-15.83), high school education (OR=2.70, 95%CI 1.27-5.75), having had a relative/friend diagnosed with CCHF (OR=2.94, 95% CI 1.08-7.96), a CCHF knowledge score ≥ 9 out of 20 (OR=3.37, 95% CI 1.61-7.07) and a knowledge score between 5 and 8 (OR=2.58, 95% CI 1.51-4.39). Conclusions: Our results showed that the study population perceived a high likelihood of CCHF risk. Improving public knowledge and awareness could result in a more realistic assessment of CCHF risk, hence better compliance with taking precaution measures to tackle the disease.