Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D₃] and urinary tract infection (UTI) among children. Methods: White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, and serum 25(OH)D₃ levels were measured in 82 children experiencing a first episode of UTI, with no risk factors for UTI, and 64 healthy control children. Results: The mean serum levels of 25(OH)D₃ among children with UTI were significantly lower than those of controls (11.7 ± 3.3 vs. 27.6 ± 4.7 ng/ml; p < 0.001). The serum levels of 25(OH)D₃ were significantly lower in patients with acute pyelonephritis compared to patients with lower UTI (8.6 ± 2.8 vs. 14.2 ± 3.0 ng/ml; p < 0.001). Within the study group, mean serum levels of 25(OH)D₃ among girls were lower than those of boys (10.9 ± 3.4 ng/ml vs. 13.2 ± 4.4 ng/ml; p < 0.001). Multivariate analysis showed that a serum 25(OH)D₃ level of <20 ng/ml (odds ratio 3.503, 95% confidence interval 1.621-7.571; p = 0.001) was associated with UTI in children. Conclusions: Our results suggest that vitamin D deficiency may be a risk factor for UTI in children.

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The MPV is a fast and reliable measurement with considerable predictive value for the diagnosis of APN and renal scars, and its predictive capacity is better than that of CRP, ESR, and WBC values.

Background and aims To investigate the association between serum mean platelet volume (MPV) levels and meconium stained amniotic fluid (MSAF). Methods MPV, serum reactive protein and haemoglobin levels, leukocyte and thrombocyte counts were measured in 106 infants with MSAF and 78 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, maternal pregnancy diseases, intrauterine infections, maternal smoking and severity of meconium aspiration syndrome were recorded. Results The mean values of MPV in infants with MSAF were significantly lower than in the control group statistically (p < 0.001). There was no statistically significant difference in haemoglobin levels, and leukocyte and thrombocyte counts in the study group compared to the control group (p > 0.05). There was no statistically significant difference in MPV levels in the infants with meconium aspiration syndrome (MAS) compared to the study group (p > 0.05). A 9.90 fl [area under the curve (AUC: 0.788)] optimal cutoff value of MPV with a sensitivity of 78.1% and specificity of 74.3% was determined in infants with MSAF. Conclusions Our data suggest that the MPV levels were significantly lower in infants with MSAF than that in healthy infants. This might be associated with hypoxic process. However, the MPV levels were statistically similar between MSAF and MAS, leading to a failure of detecting patients with or without severe disease. Abstract PS-095a Table 1

After 48 h of treatment a significant decline in bicarbonate levels (from 35,3 ± 4,7 to 31,1 ± 3,9 mmol/L, p < 0,001), pH (from 7,45 ± 0,05 to 7,41 ± 0,06, p < 0,001), and PCO2 (from 52.9 ± 10 to 51,2 ± 10 mmHg, p = 0,002) were found, whereas anion GAP increased (from 6,8 ± 9,8 to 8,7 ± 3,8, p = 0,001). Mechanical ventilation was in use in 102 patients, (31,6% were extubated during acetazolamide treatment).Average Acetazolamide dose was 8,46 mg/Kg/day. None of the patients suffered from serious side-effects attributable to Acetazolamide. Conclusions Acetazolamide treatment improved metabolic alkalosis secondary to diuretic treatment in critically ill children, contributing to a decrease in PaCO2. Enteral administration was effective and well tolerated without serious adverse effects. Background and aims There is increasing evidence that vitamin D deficiency plays an important role in susceptibility to infections. We aimed to examine whether there is any association between serum levels of 25-hydroxy vitamin D (25(OH)D3) and urinary tract infections (UTI) among children. Methods Serum calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D3 levels were measured in 82 children aged 2 months to 12 years with first episode of UTI, not having any risk factor for UTI, and 64 healthy control children. The age, gender, weight, height, fever, vitamin D or calcium supplementation, urinalysis and urine culture were recorded. Results The serum levels of 25(OH)D3 were significantly lower in the study group compared to healthy control group (11.69 ± 3.25 ng/mL vs. 27.57 ± 4.72 ng/mL; p < 0.001). There was statistically significant difference in serum 25(OH)D3 levels between the patients with upper UTI compared to the patients with lower UTI (8.63 ± 2.76 ng/mL vs. 14.22 ± 2.97 ng/mL; p < 0.001). The serum levels of 25(OH)D3 were significantly lower in girls compared to the boys in the study group (10.91 ± 3.42 ng/mL vs. 13.20 ± 4.38 ng/mL; p < 0.001). Multivariate analysis showed that a serum 25(OH)D3 level of < 15 ng/mL (odds ratio 3.50, 95% confidence interval 1.62-7.57; p = 0.001) was associated with UTI in children. Conclusions Our results suggest that vitamin D deficiency is a risk factor for UTI in children and low serum level of vitamin D in girls is one of the reason for prone to UTI. PS-244a IS VITAMIN D DEFICIENCY