same period were collected for this case-control study. All patients had measured laboratory data including total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, apolipoprotein B, and apolipoprotein A-I. A total of 434 consecutive patients pathologically diagnosed gastric cancer were prospectively enrolled between December 2013 to March 2017, and 3053 controls from Health Promotion Center who received health examination during the same period were collected for casecontrol. All patients had measured laboratory data including total cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, apolipoprotein B, and apolipoprotein A-I.Results: After adjusting for age and gender, lower HDL level (< 40 mg/dL, adjusted OR ¼1.629, 95% CI¼1.252e2.119), higher LDL levels (LDL¼100-129 mg/dL: adjusted OR¼1.742; LDL¼130-160: adjusted OR¼1.857; LDL160: adjusted OR¼1.663), and lower apolipoprotein A-I level (< 178 mg/dL, adjusted OR¼1.795, 95% CI¼1.190e 2.710) were significantly associated with an increased risk of gastric cancer. After adjusting multivariate factors including age, gender, Helicobacter pylori infection, body mass index, smoking status, alcohol drinking status and family history of gastric cancer, higher LDL level (LDL¼100-129 mg/dL: adjusted OR¼1.655; LDL¼130-160: adjusted OR¼1.787) and lower apolipoprotein B (adjusted OR¼1.381, 95% CI¼1.034e1.848) were identified as significant factors for gastric cancer. In subgroup analysis of gastric cancer patients, triglyceride level was inversely correlated with advanced cancer stage and poor differentiation.
Conclusion:Low serum HDL level, high LDL level, low apolipoprotein A-I and lower apolipoprotein B level were significantly associated with increased risk of gastric cancer, and low triglyceride level was correlated with advanced cancer stage and poorer differentiation.Legal entity responsible for the study: The authors.