not mobilized had PICU LOS less than 24 hours and 12.2% of patients were not mobilized for medical reasons. There was no statistical difference between PICU LOS (pre-EM: 11.7±15.7 days, post-EM: 8.3±13.9 days, p=.187) and hospital LOS (pre-EM: 37.7±43.7 days, post-EM: 33.9±51.6 days, p=.986) between both cohorts.
CONCLUSIONS:The early mobilization program was associated with significant improvements in the percentage of patients mobilized and time to mobilization.
540 Background: The rate of venous thromboembolism (VTE) in (mCRC) with bevacizumab was reported in a meta-analysis as 19.1%. We estimated and compared the rate of VTE among mCRC patients receiving FOLFIRI and bevacizumab with patients receiving FOLFIRI without bevacizumab. Methods: We conducted a retrospective cohort study assessing the rate of VTE in a group of 450 mCRC patients seen consecutively at the Juravinski Cancer Center. Patients were classified according to their treatment: chemotherapy plus bevacizumab group (n=261) and control group (n=189) who received only FOLFIRI during the years 2004 to 2012. Demographic, pathologic and treatment data were abstracted. Multivariate analysis was used to adjust for the effect potential confounding variables associated with treatment and VTE and to assess the effect of these variables risk of VTEs in this population. The primary end point was the occurrence of a VTE. Secondary analyses involved classifying site of VTE. Results: The percentage of male, mean age and mean BMI were 64.8%, 60.1 years and 27.2 for the bevacizumab group and 61.9%, 63.69 years and 27.6 are for the control group. The crude incidence of VTEs was 13.1% in bevacizumab and 10.5% in the control groups (p = NS). Multivariate analysis controlled for age, BMI, gender, malignancy, metastatic disease and line of treatment did not suggest a significant increase in risk of VTE associated with bevacizumab (OR=0.83 95% CI: 0.40, 1.70; p=0.602). The only significant factor for thrombosis in bevacizumab group was BMI (OR=1.05; 95% CI: 1.01, 1.10; p=0.016). Other risk factors such as previous VTE, stroke, smoking, and hypertension were not statistically significant when assessed through a composite covariate. For anatomical location of VTEs, see the Table. Conclusions:The rate of VTEs overall was lower in our sample than has been reported in previous studies. We excluded upper limb DVTs associated with central lines which may explain the lower VTEs overall. The incidence of VTEs was not significantly different between the bevacizumab and the control groups. bevacizumab was not associated with increase risk of VTES . This support the safety of bevacizumab in regards to VTEs risk in this population. The incidence of venous thromboembolism (VTE) in FOLFIRI with and without bevacizumab. [Table: see text]
Background: The past two decades have seen an increase in survival of patients with limited stage small cell lung cancer (SCLC). This retrospective audit analyzed patterns of care, toxicity and survival for all patients with limited stage SCLC diagnosed and treated at Prince of Wales hospital over 15 years. Our results were compared with the literature to assess this single institution's performance and outcomes, and explore what factors may most be influencing these results.Background: The primary lung neuroendocrine tumors (NET) are uncommon. They have a wide spectrum of clinical behavior, currently being classified into four
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