The main objectives of present work was to design and evaluate pellets of Carvedilol in order to increase patient compliance and therapeutically benefits. The pellets were made by the sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in stomach for long time. Hence sodium bicarbonate and hydroxyl propyl methyl cellulose are the key ingredients of this dissertation work. In vitro release trials were evaluated in response to check release of drug from the drug coated spheres. The release pattern of batches T1 to T6 was observed to vary due to variation in the concentration of HPMC 5cps, low substituted HPC and PVP K30. The trials T1-T3 showed the slow drug release due to combination of PVP K30 with low substituted HPC and HPMC 5cps; while the formulation T4-T6 showed the good release behavior as compare to T1-T3.
The main objectives of present work was to design and evaluate modified releasing pellets of drug, Carvedilol, in respect to increase patient compliance and therapeutically benefits. The modified releasing pellets were made by the sub-coating with sodium bicarbonate and hydroxyl propyl methyl cellulose which was utilized to keep the spheres in stomach for long time. To get modified release of active pharmaceutical ingredients from the pelletizing process, they were coated with methacrylic acid co-polymer (Eudragit NE 40D). Hence sodium bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D are the key ingredients of this dissertation work. Concentration of sodium bicarbonate, hydroxyl propyl methyl cellulose and eudragit NE 40D in coating suspension was optimized by initial studies and factorial design. The procedure based optimization analysis also perform to optimize process factors like product temperature and spraying rate to improve physical parameters and micromeritic characteristics of spheres by preliminary data.
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