The present cross-sectional study was conducted in the Department of Pathology, Dhaka Medical College Hospital, Dhaka over a period 12 months to evaluate the usefulness of intra-operative imprint cytology in diagnosing various breast lesions and to compare its diagnostic accuracy with those of frozen and paraffin sections. A total of 101 cases of breast tumours, diagnosed clinically or mamographically, who underwent elective surgery were consecutively included in the study. The mean age of the patients was 37.7 – 14.5 years. The sensitivity and specificity of imprint cytology in differentiating breast carcinoma from those who did not have breast carcinoma were 91% and 94.1% respectively. The positive and negative predictive values (PPVs and NPVs) of the test were 96.8% and 84.2% respectively. The percentages of false positive and false negative were 3.2% and 15.8% respectively. The overall diagnostic accuracy of imprint cytology was 92%. The sensitivity of frozen sections in correctly diagnosing carcinoma of breast was 95.5%, while the specificity of the test in ruling out those who did not have carcinoma was 97.1%. The positive and negative predictive values of the test were 98.5% and 91.7% respectively. The percentages of false positive and false negative were 1.5% and 8.3% respectively. The overall diagnostic accuracy of the test was 96%. The overall diagnostic accuracy of the two procedures is almost comparable. However, the imprint cytology has merit over frozen section in that it can be done quickly and thus helps operating surgeons to decide about margin clearance. JCMCTA 2013 ; 24 (2): 4-8
Background & objective: The importance of establishing hormone receptor status of tumors for the treatment of women with hormone receptor-positive breast cancer is often emphasized. It is critical to evaluate hormone receptor status when considering response to endocrine therapy. The present study was intended to evaluate the usefulness of hormone receptor status in breast carcinoma. Materials & Methods: The present study was conducted in the Department of Pathology, Dhaka Medical College, Dhaka over a period 12 months from July 2009 to June 2010. A total of 30 histopathologically diagnosed cases of breast tumors who were also subjected to immunohistochemical (IHC) test for ER, PR status and HER-2/neu were consecutively included in the study. Patients who have already been treated for malignancy or who had a history of receiving radiotherapy were excluded. Result: Age distributions shows that 40% of the patients were early middle-aged (30-40 years), 30% middle-aged and the rest were either < 30 years or >50 years old. Left breast was involved more often (56.7%) than the right breast (43.3%). The predominant location was upper outer quadrant (43.3%), followed by upper inner quadrant (20%), lower outer quadrant (20%), lower inner quadrant (10%) and central (6.7%). Over half (53.3%) of the tumors were < 5 cm and the rest 5 cm or more. Nearly half (46.7%) of the tumors were moderately differentiated, 36.6% well-differentiated and 16.7% poorly differentiated. In majority (83.3%) of the cases lymph-nodes (axillary lymph nodes) were involved. Based on estrogen and progesterone receptor status, over half (53.3%) of the tumors were ER and PR positive and 40% were Her2/neu overexpressed. Conclusion: The study concluded that half of the Bangladeshi breast cancer patients are ER and PR positive and two in every five cases are Her2/neu overexpressed. J Shaheed Suhrawardy Med Coll, December 2018, Vol.10(2); 70-73
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