?-Tricalcium phosphate/fluorapatite (?-TCP/FAp) mixed powders were prepared
in order to obtain dental root canal filling cements. Different liquids for
cement pastes have been investigated and the most suitable one for obtaining
rheologically optimal pastes was chosen for further analysis. Morphological
changes in the cement materials as a consequence of the formation of
hydroxyapatite (HAp) after the immersion in a simulated body fluid (SBF), an
influence on the cell viability, and final success of the filling were
investigated by field emission scanning electron microscopy. Treatment of
the ?-TCP/FAp mixtures in SBF at 37?C resulted in a complete transformation
of ?-TCP into HAp after 10 days, while the exposure of MRC-5 human and L929
animal fibroblast cells to the cement showed complete absence of
cytotoxicity. The root canal of an extracted tooth was filled with the
?-TCP/FAp cement containing 5 wt.% of FAp and relatively strong adhesion
between the cement and dentine was observed after 48h. The same cement
material was immersed during 10 days in SBF and after that both human and
animal fibroblast cells during in vitro MTT tests showed higher cell
viability compared to the control sample. These findings lead to a
conclusion that the ?-TCP/FAp based cement demonstrates potential for
further development towards dental cement application.
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