Background: Prurius is the most common reason that obstetrics receive a treatment after intrathecal opioids. Which is characterized by an unpleasant, localized and/or generalized sensation on the skin and mucous membranes. It deserves the same degree of clinical attention as pain. Its incidence is 30–100% and having special increment in case of obstetric patients 60–100%. Methods: Institution based double blinded randomized controlled clinical trial was conducted in 93 patients undergoing cesarean section under spinal anesthesia with 25 μg fentanyl and 12.5 mg bupivacaine were included. Data was entered by coding and analyzed by using SPSS version 20 software package and pruritus was analyzed using cross-tabulation (chi-square test) and presented in frequency and percentage. Severity of pruritus was compared by using Mann Whitney U test for statistical significant difference between groups. P-value < 0.05 was considered as statistically significant at power of 80%. Results: The comparison of data showed that the incidences of pruritus in treatment group (14%) were significantly reduced with compared to placebo group (36%) approximately by 2.6 times at p-value (0.01). The overall severity of pruritus was mild (85.7% vs 47.4%), moderate (14.3% vs 47.4%) and severe (0.0% vs. 5.3%) between ondansetron and placebo groups respectively but not statistically significant. Conclusions: Prophylactic use of IV ondansetron significantly reduced the incidence of intrathecal fentanyl induced pruritus compared to placebo groups in patients undergoing cesarean section under spinal anesthesia. Highlights:
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.