We have presented an explicit relationship between SaO(2) and its direct determinants during VV-ECMO. Good agreement was found with the measured values of SaO(2), but the model remains to be fully validated before its use in clinical practice.

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an important tool in the management of most severe forms of acute respiratory failure. The determinants and management of oxygen delivery in patients treated with VV-ECMO is a complex topic. The physiological principles of oxygenation on VV-ECMO are reviewed in many textbooks. However a numerical model is an additional instrument to be used in understanding and exploring this intricate subject matter. We present a numerical model of blood oxygenation during VV-ECMO. Using this model we examined the role and impact of each determinant on blood oxygenation. The numerical analysis of variation and interplay between each oxygenation determinants during VV-ECMO is presented in graphical form. These results corroborate all the findings of previous studies. The proposed numerical model facilitates understanding of oxygenation physiology during VV-ECMO; it can be used for a medical simulation system and for teaching the principles of oxygenation during VV-ECMO.

If hypoxemia occurs during VV-ECMO, collecting oxygenation parameters and a clear step-by-step algorithm could guide specific intervention to improve oxygenation. This flow diagram is in accordance with current recommendations recapitulated in guidelines or troubleshooting chart but more accurate and complete. Although rational and appealing, it remains to be tested together with a number of still unsolved issues.

No abstract

This study aimed to explore the electronic, magnetic, and magneto-optical properties of double perovskites Ca2FeIrO6 and Ca2CoIrO6 to examine their potential applications in spintronic and photovoltaic devices. The calculations were done using the full-potential linearized augmented plane wave within the density functional theory. For the electronic exchange-correlation function, we used the generalized gradient approximation (GGA) and GGA+U (Hubbard potential), and spin-orbit coupling (SOC). The study showed that Ca2FeIrO6 and Ca2CoIrO6 exhibit a monoclinic structure (space group P21/c). The structure relaxation shows an antiferromagnetic behavior in both systems with a magnetic moment of about 6.00 µB for Ca2FeIrO6 and 4.00 µB for Ca2CoIrO6 by using GGA+U approximation. GGA and GGA+U computations predict half-metallic behavior for both. The magneto-optical polar Kerr effect (MOKE) was examined by studying the variation of Kerr and ellipticity rotation. The Kerr rotation angle is 1.3° at 4.82 eV and −1.21° at 4.3 eV, and the ellipticity angle is −1.21° at 4.3 eV for Ca2FeIrO6. In the case of Ca2CoIrO6, the Kerr rotation angle is −1.04° at 4.05 eV; the significant Kerr rotation in both 1 Springer Nature 2021 L A T E X template Properties of the Double Perovskites Ca 2 TMIrO 6 (TM=Fe, Co) compounds may suggest the application of these materials in optoelec-tronics bias. The named compounds have the potential application in the field of spintronics and its devices, as in optoelectronics technologies.