Our data support a critical role of the CYP3A5 6986A>G and CYP3A4 -392A>G polymorphisms on the variation of Tac exposure during the early and the late PT phase, respectively. The establishment of customized Tac doses, according to CYP3A4/CYP3A5 genotype combination and the PT time, may allow preventing graft rejection and improving the safety profile of this drug. Further studies are needed to investigate this issue.
The original version of this Article omitted the word "of" in the title and should have read "Influence of CYP3A polymorphisms on tacrolimus pharmacokinetics in kidney transplant recipients". This has now been corrected in both the PDF and HTML versions of the Article.
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