Background: Allergic rhinitis is atopic disorder, 10% to 25% of the population
worldwide are suffering from it, The prevalence is increasing during the last 10 years.
Objectives: To study the relationship among polymorphism of single nucleotide in TLR2
and TLR4 genes and the risk of allergic rhinitis disease. Methodology: This study was
done on 60 patients suffering from allergic rhinitis and 30 healthy subjects as a control
group from April 2019 to March 2020. The patients were collected from
Otorhinolaryngology Department of Benha University Hospital. Test of Skin prick (SPT)
was done to assess atopic state. Blood samples were collected to detect TLR gene
polymorphism by Polymerase chain reaction-Restriction Fragment Length
Polymorphism (PCR-RFLP). Results: The genotypic frequencies of TLR2 Arg753Gln
showed increased frequency of the homozygous (GG) genotype among the controls
(80%) more than the allergic rhinitis patients (30%). The heterozygous (AG) genotype
was increased among the allergic rhinitis patients (62.5%) more than in the healthy
group (15%) with OR =9.4, 95% CI (2.4-37.7) and significant P-value. Also, the
homozygous mutant (AA) genotype has more trend in the patients (7.5%) than in the
control subjects (5%), with OR = 0. 6, 95% CI (0.1-6.7) and non-significant P-value.
The genotypic frequencies Statistical data in TLR4 Asp299Gly revealed that the
homozygous (AA) genotype has more frequency in the controls (70%) than the allergic
rhinitis patients (20%). The heterozygous (AG) genotype was more prevalent among the
allergic rhinitis patients (65%) than the controls (30%) with OR =4.3, 95% CI (1.4-13.8)
and significant P-value. Conclusion: GG genotype of TLR2 and AA genotype of TLR4
are least affected by allergic rhinitis disease and the major allele in both gene is
protective against the disease.
Background: Adenoid hypertrophy (AH) plays an important role in chronic rhinosinusitis and chronic otits media in children. Children may frequently have recurrent upper and lower respiratory tract infection. Objectives: To assess anti leukotrienes effect on CD64 expression on surface of monocyte cells in children complaining of adenoid hypertrophy. Methodology: This study was conducted on Patients diagnosed with adenoid hypertrophy at
Background:. Atrophic rhinitis is a chronic inflammatory condition of the nasal mucosa which remains as persistent illness and of difficult management. Objectives: -are to evaluate the relation between microbiological flora present in the nose and pathogenesis of primary atrophic rhinitis disease and to detect the antibiotic susceptibility of these microorganisms and detection of the prevalence of Ampc beta lactamase gene among isolated strains. Methodology: This study was done on samples collected from 60 patients attending the Outpatient Clinic of Otorhinolaryngology at Benha University Hospital, collected during the period from February 2019 to September 2019. Bacterial cultures from nasal crust, or discharge were done for isolation of the pathogenic bacteria and detection of their antibiotic susceptibility by Vitek-2 system,multiplex PCR was done to detect AmpC gene in isolated strains. Results: Klebsiella ozeana was isolated in 24 (40%) of the patients followed by Pseudomonas aeruginosa in 12 cases (20%). Klebsiella species showed 5%, 45%, and 65% susceptibility to first, second, and third generation cephalosporins, respectively. It also showed 64% susceptibility to quinolones and 42% susceptibility to amoxycillin plus clavulanic acid. The susceptibilities of the isolated Pseudomonas aeruginosa strains to antibacterial agents were 12%, 59%, and 70% to first, second, and third generation cephalosporins, respectively, and 64% susceptibility to quinolone. From the 45 enterobactericae isolates, 21 (46.7%) were AmpC β-lactamase isolates [13/24 (54.2 %) K.ozeanea, 5/12 (41.7%), 2/6(33.3%) E. coli, 1/3(33.3%) P. mirabilis Conclusion: The bacterial infection of nasal mucosa is the main trigger in patients complaining of primary atrophic rhinitis .
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