Abstract. Naringin is a citrus-flavonoid which has been shown to have positive metabolic and anti-inflammatory effects. For this reason, we believe it would be interesting to study the effects of Naringin administration on body weight, BMI, lipid profile and adiponectin levels in patients with dyslipidemia, especially considering that dyslipidemias along with obesity and subsequent cardiometabolic complications are some of the most important public health issues plaguing our society today. A double-blind, randomized clinical trial was conducted in a group of 28 adult patients previously diagnosed with dyslipidemia who attended the Institute of Experimental and Clinical Therapeutics. Patients were divided into two groups; the first group (n = 14) received 450 mg of naringin every 24 hours, in the mornings, while the second group (n = 14) was given a homologated placebo over the course of a 90-day period. Significant differences were observed in naringin group compared to the placebo group in terms of decreased BMI (30.6 ± 3.19 vs 33.3 ± 3.23 kg/m2; p = 0.03), total cholesterol (182 ± 20.2 vs 245 ± 24.1 mg/dl; p < 0.01), LDL cholesterol (100 ± 17.5 vs 125 ± 38.3 mg/dl; p = 0.03) and an increase in adiponectin levels (0.82 ± 0.25 vs 0.59 ± 0.19 μg/ml; p = 0.01). Our results support the use of Naringin as a potential therapeutic agent which could play an important role in the management of metabolic disorders.
ObjectivesThe aim of this study was to investigate the effects of Cassia acutifolia on the obesity and the glucose levels in a rat model of obesity and diabetes.MethodsBy random selection, 36 Wistar male rats were divided in two control groups, the positive and the negative control groups, and into four experimental groups receiving different infusions of Cassia acutifolia in water ad libitum.ResultsThe results revealed a statistically significant anti-obesogenic effect (P = 0.02), although this was not considered clinically significant. Additionally, Cassia acutifolia lowered the glucose levels by 30 mg/dL to 90 mg/dL (P = 0.05). However, we observed adverse effects in the liver, a two-fold increase in transaminase levels (P = 0.002), and in the kidneys, decreased creatinine levels (P = 0.001), and these adverse effects had no viable explanation.ConclusionCassia acutifolia has anti-hyperglycemic effects in obese diabetic rats. However, Cassia acutifolia also has adverse effects, so it should not be administered to patients.
Introducción: La naringina es un flavonoide utilizado como suplemento alimenticio, el cual es comercializado en productos para atletas, se promueve como: potenciador de otros suplementos, aumenta la capacidad física y como "quemador de grasa" para la pérdida de peso, entre otros efectos. Objetivo: evaluar la evidencia disponible del efecto de la suplementación oral de naringina en combinación con actividad física y/o ejercicio en respuestas clínicas en comparación con solo actividad física y ejercicio.Material y métodos: Se realizó una búsqueda sistemática en bases de datos electrónicas. Fuentes de datos: Science Direct, MEDLINE, PubMed, Web of Science, Registro Cochrane Central de ensayos controlados, SPORTDiscus. Selección de estudios: Publicaciones con el objetivo de estudiar los efectos de la naringina en combinación con ejercicio o actividad fisica. Extracción de datos y método de síntesis: Se realizó analisis por dos revisores, datos extraídos: autores, año de publicación, diseño del estudio, universo de estudio, intervención y resultados relevantes; se cuantificó la calidad con la escala PEDro. La revisión fue realizada siguiendo los lineamientos PRISMA.Resultados: Se identificaron 3 ensayos clínicos (escala de PEDro media de 8,3). Naringina mejora el tiempo de actividad física y disminuye el tiempo fatiga, y mejora subjetivamente la condición física pero no resultó estadísticamente mejor al placebo.Conclusiones: Los estudios muestran contradicciones sobre los efectos de la combinación sobre la condición física.
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