The effect of Matricaria chamomilla (M.chamomilla) against hepatic-renal toxicity of Ceftriaxone was investigated in this study. Twenty eight rats were divided into four groups. The 1 st group was injected with saline as control, the 2 nd and 3 rd groups were injected with M.chamomilla extraction ( 50mg/kg.b.wt) andwith ceftriaxone ( 180 mg/kg.b.wt.) for two and one week respectively while the 4 th group was injected with M.chamomilla extraction plus ceftriaxone. at dose 50mg/kg and 180 mg/kg.b.wt respectively ,daily for the one week and with M.chamomilla extraction only at dose 50mg/kg.b.wt for another week. At the end of the 1 st week, the 3 rd group had significantly higher ALP,ALT,AST, urea and creatinine levels with significantly lower albumin and A/G ratio levels than that of the 1 st and2 nd groups , while the 4 th group did not differ from 1 st and 2 nd groups in terms of these parameters. Histopathological studies revealed that, the 3 rd group had some pathological changes in the liver and kidney. From this study we can conclude that, M. chamomilla extraction can reduce hepatic-renal toxicity of ceftriaxone in rats.
Postpartum haemorrhage is defined as blood loss of 500 millilitres or more within 24 hours after a vaginal or c-section birth (WHO 2018). Hypovolemia occurs when more than 1,000mL of blood is lost in the first 24 hours after birth. A postpartum haemorrhage is defined as the loss of more than 1000 ml of blood after a caesarean operation. During and after caesarean surgery, the effectiveness and safety of intravenous carbetocin, an analogue of oxytocin, was compared against intravenous oxytocin and intramuscular ergometrine for the prevention of postpartum haemorrhage. Researchers used a randomised, prospective strategy for the study Researchers at Benha University Hospital's Obstetrics & Gynecology department worked from January 2020 to November 2021. A total of 120 people are taking part in the research. Group A received carbetocin 100g intravenously after the birth of their second child in this trial. Patients in Group B received oxytocin 10IU intravenously and ergometrine 0.02 mg intramuscularly as a combination treatment for 60 patients. Results: Estimated blood loss was significantly different between groups given carbetocin. Carbetocin, rather than oxytocin and ergometrine, is more likely to prevent atonic postpartum haemorrhage in a woman who has had several pregnancies and is undergoing a caesarean section.
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