Recently, quinoline has become an essential heterocyclic compound due to its versatile applications in the fields of industrial and synthetic organic chemistry.
Introduction
In the present work, two novel compounds were synthesized using zinc oxide nanoparticles through green synthesis protocol. The zinc oxide nanoparticles catalyzed reactions were afforded good to excellent yields of the target compounds 76.3–98.6%.
Methodology
The synthesized compounds were characterized by UV-Vis, IR and NMR. The antibacterial activity of the synthesized compounds was screened against two Gram-positive bacteria (
Bacillus cereus
and
Staphylococcus aureus
) and two Gram-negative bacteria (
Escherichia coli
and
Salmonella typhimurium
).
Results and Discussion
The synthesized compounds displayed potent activity against the bacterial strains. Among them, compound
8
showed strong activity against
Bacillus cereus
relative to the standard drug. On the other hand, compound
9
exhibited strong activity against
Escherichia coli
. The molecular docking study of the synthesized compounds was conducted to investigate their binding pattern with DNA gyrase and
E. coli
dihydropteroate synthase and all of them were found to have minimum binding energy ranging from –6.0 to −7.3 kcal/mol, and the best result achieved with compound
8
and
9
.
Conclusion
The findings of the in vitro antibacterial and molecular docking analysis demonstrated that the synthesized compounds have potential of antibacterial activity and can be further optimized to serve as a lead compound.
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