Vapor pressures of five saturated fatty acid ethyl esters (FAEEs), ethyl hexanoate (or ethyl caproate), ethyl octanoate (or ethyl caprylate), ethyl decanoate (or ethyl caprate), ethyl dodecanoate (or ethyl laurate), and ethyl tetradecanoate (or ethyl myristate), were measured at pressures from 1 Pa to 180 kPa and temperatures from (253.15 to 463.15) K using a static apparatus. These esters are a light fraction present in biodiesel derived from palmist oil and copra oil (Ballerini and Alazard-Toux, Les biocarburants; IFP Publications: Paris, 2006). The experimental data (P–T) were smoothed using the Antoine equation and compared with the available literature values. The molar enthalpies of vaporization at the mean temperature of the experimental range were derived from the Clausius–Clapeyron equation. From these results the standard enthalpies of vaporization at T = 298.15 K were calculated.

One of the main challenges posed by the emergence of new psychoactive substances is their identification in human biological samples. Trying to detect the parent drug could lead to false-negative results when the delay between consumption and sampling has been too long. The identification of their metabolites could then improve their detection window in biological matrices. Oxidative metabolism by cytochromes P450 and glucuronidation are two major detoxification pathways in humans. In order to characterize possible CYP- and UGT-dependent metabolites of the 2-(4-bromo-2,5-dimethoxy-phenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25B-NBOMe), a synthetic psychoactive drug, analyses of human liver microsome (HLM) incubates were performed using an ultra-high performance liquid chromatography system coupled with a quadrupole-time of flight mass spectrometry detector (UHPLC-Q-TOF/MS). On-line analyses were performed using a Waters OASIS HLB column (30 x 2.1 mm, 20 µm) for the automatic sample loading and a Waters ACQUITY HSS C18 column (150 x 2 mm, 1.8 µm) for the chromatographic separation. Twenty-one metabolites, consisting of 12 CYP-derived and 9 UGT-derived metabolites, were identified. O-Desmethyl metabolites were the most abundant compounds after the phase I process, which appears to be in accordance with data from previously published NBOMe-intoxication case reports. Although other important metabolic transformations, such as sulfation, acetylation, methylation or glutathione conjugation, were not studied and artefactual metabolites might have been produced during the HLM incubation process, the record of all the metabolite MS spectra in our library should enable us to characterize relevant metabolites of 25B-NBOMe and allow us to detect 25B-MBOMe users.

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