Background: This condition is known as preeclampsia, which is characterized by new-onset hypertension after twenty weeks of gestation with indications of organ damage; the potential maternal and neonatal consequences of preeclampsia are considerable. Aim of the work: The study's goal is to determine the function and efficiency of low molecular weight heparin in avoiding severe preeclampsia.
Patients and methods:The study is randomized, interventional study and carried out on cases of high risk of pre-eclampsia at obstetrics, gynecology department al-azhar university hospitals. Our study was done on one hundred participants of high risk of pre-eclampsia separate into 2 groups; Group 1 (study group): in accordance with standard regimen, 50 patients got low molecular weight heparin. Group 2 (control group): contain 50 cases had received usual regimen only.
Results:The current results show statistically significant differences between groups according to patient's clinical improvement, APGAR score and NICU admission with more improvement in patients who received low molecular weight heparin in accordance with usual regimen when it compared to other group which contain cases received usual regimen only (control group). Conclusion: low molecular weight heparin is effective in preventing development of severe preeclampsia in patients with mild preeclampsia on expectant management of this resulting in less maternal, fetal and neonatal morbidity and mortality.
Background:In spite the fact that the prevalence of preterm birth has increased, several treatments have been identified as having a possible role in reducing the risk of repeated preterm birth (PTB), such as bed rest and vaginal progesterone, which have been tried to ameliorate this distressing condition. Objective: To compare the efficacy of vaginal progesterone and cerclage in preventing preterm birth. Patients and Methods: This study was a prospective cohort randomized clinical study that was conducted on 120 pregnant women at high risk of preterm birth; 60 cases were prescribed vaginal progesterone and the remaining 60 cases underwent cervical cerclage. They were all chosen from the outpatient clinics at Al -Hussien university Hospital and Kafr EL-Sheikh General Hospital during the period from March 2020 till December 2020. Results: It was observed that in cases who received vaginal progesterone the mean gestational age was (35.76±2.33 weeks) while it was (36.32±2.12 weeks) in those who underwent cerclage. The mean gestational age improved in the cerclage groups by about 3.92 days. The gestational age at delivery was higher in the cerclage group than that in the progesterone group, but without significant difference. As regard neonatal outcome of the current delivery, the overall morbidity was shown in 22 cases (19.8%) and mortality was 5 (4.5%).
Conclusion:Both vaginal progesterone as well as cervical cerclage had a significant beneficial impact in opposition to preterm delivery and improving perinatal consequences among the high-risk singleton pregnant ladies with former spontaneous PTB.
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