No abstract

<p>Chikungunya fever (CF) has recently re­emerged as a major public health problem of global scale. It is characterized by an acute onset of high fever associated with severe disabling arthritis, vomiting, sore throat and often with prominent cutaneous manifestations. The disease is usually self-limiting, but the joint symptoms and some cutaneous features may persist after defervescence. Various cutaneous changes have been described in association with CF. We report a case series of ten patients presenting with pigmentation (over face, palm, sole, knuckles, fingers) and vesiculobullous lesions which were diagnosed as chikungunya rash based on of clinical and serological investigation.</p>

<p class="abstract">Cutaneous tuberculosis occurs by either exogenous inoculation in a previously sensitized or non-immune host or endogenous spread from an internal focus by contiguous, hematogenous or lymphatic route. Inoculation occurs at sites of minor wounds or abrasions, sometimes from the patient’s own sputum. Cutaneous tuberculosis includes lupus vulgaris and tuberculosis verrucosa cutis (TVC) at one end and scrofuloderma and tuberculosis cutis orificialis at the other end with decrease in cell-mediated immunity across the spectrum. Of various cutaneous forms, we report a case of tuberculosis verrucosa cutis in a 14 year old girl who presented with a hyperpigmented verrucous plaque over foot since three years. Histopathological characteristics, GeneXpert and response to antitubercular therapy confirmed the diagnosis.</p><p class="abstract"> </p>

Progressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis. It is characterized by progressive appearance of papules and nodules without spontaneous resolution. We report a 60-year-old patient with novel clinical features in the form of extensive noduloulcerative lesions, ichthyotic patches, and laryngeal involvement culminating in fatal outcome prior to therapeutic intervention. Although the presenting features were baffling, histopathology and immunohistochemistry clinched the diagnosis of PNH.

Although HIV infection can mimic the manifestations of various autoimmune disorders, the coexistence of HIV and systemic lupus erythematosus (SLE) has been rarely reported. The exact impact of HIV on SLE and vice versa is unclear. We report an HIV-seropositive female on highly active antiretroviral therapy presenting with features of SLE. Herein, an attempt has been made to discuss the various complex clinical and therapeutic implications along with the influence on disease course and prognosis.

<p style="margin-bottom: 0in; line-height: 100%;" align="JUSTIFY">Kimura’s disease is a rare chronic inflammatory disease of unknown etiology, presenting as painless subcutaneous nodules with lymphadenopathy and peripheral eosinophilia, mainly disturbing the head and neck region. It mainly affects Asian males in their 2nd to 4th decade of life. Kimura’s disease, although difficult to diagnose clinically, should be considered in the differential diagnosis of patients who have a primary lymphadenopathy with eosinophilia with or without subcutaneous nodules. It should be investigated accordingly as the disease has an indolent course and good prognosis. Herein we report two cases of Kimura’s disease, of which one had unusual site of involvement. </p>

<p class="abstract"><span lang="EN-IN">Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder of blood and lymphatic vessels that is characterised by a combined vascular malformation of the capillaries, veins and lymphatics, congenital abnormalities, and associated limb hypertrophy. It may also involve gastrointestinal tract which can lead to life threatening bleeding. This syndrome presents since birth to early infancy or childhood with equal distribution in both genders. An adolescent female presented with right lower limb hypertrophy with port wine stain and overlying hemorrhagic vesiclessince birth. Histopathology of these hemorrhagic vesicles angiokeratoma. On the basis of history and classical clinical triad patient was diagnosed as KTS with angiokeratoma, an association rarely reported in literature.</span></p>

<p>Nevus of Ota is dermal melanocytosis, generally presents as blue-black or gray-brown patchy diffuse pigmentation. Most commonly occurs unilaterally on face in areas innervated by the first and second divisions of trigeminal nerves. Bilateral involvement and oral mucosal involvement can occur, but as a rare manifestation. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. The halo nevus may be seen in congenital or acquired melanocytic nevi. Presence of halo nevus in conjunction with two different dermal nevi is not reported till date. We are reporting 19 year old female presented with bilateral Nevus of Ota with oral mucosal involvement and associated nevus of Ito and halo nevus.</p>