The “on-demand” economy is built upon company strategies of arbitrage between worker autonomy and worker control. Using ethnographic and interview data, I show how these strategies undermine the economic theory that justifies the on-demand business model. The increased freedom and flexibility on offer to workers is countered by “softer” and less visible forms of workforce surveillance and control. These take hold through information asymmetries, which narrow workers’ decision-making capacities and thus undercut arguments for workers’ designation as independent contractors. However, I also show that these forms of control ultimately hinge on workers’ willingness to conform to the calculative rationalities that companies project onto them, and that workers’ motivations diverge from these company assumptions. I conclude by countering the notion of calculability with that of “qualculation,” an affective style of reasoning that workers employ in response to algorithmic workforce management and which highlights how on-the-job decisions are made within a shifting moral economy of work.

On‐demand service firms secure market power by cultivating and operationalising calculative asymmetries between the platform and labour. In this article, I analyse dynamic (or ‘surge’) pricing as an exemplary calculative technique. I show how the asymmetrical application of price‐setting allows firms to leverage control at the aggregate level while maintaining the façade of autonomy at the individual level, thereby legitimising workers’ classification as independent contractors but solving the coordination problems that the classification introduces. The article complements and extends previous critical research into the platform or ‘on‐demand’ service economy by analysing how management scientists model and simulate on‐demand marketplaces. I consider management science to be a calculative technique for optimising operational efficiency. A critical review of management science provides novel insights into platforms’ efforts to monopolise calculative agency at the expense of other market participants. The article concludes by considering implications for broader critiques of platform labour management.

Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these “silent” variations can have a significant impact on protein expression and function and should no longer be considered “silent”. Here, the effects of six synonymous and six non-synonymous variations, previously found in the gene of ADAMTS13, the von Willebrand Factor (VWF) cleaving hemostatic protease, have been investigated using a variety of approaches. The ADAMTS13 mRNA and protein expression levels, as well as the conformation and activity of the variants have been compared to that of wild-type ADAMTS13. Interestingly, not only the non-synonymous variants but also the synonymous variants have been found to change the protein expression levels, conformation and function. Bioinformatic analysis of ADAMTS13 mRNA structure, amino acid conservation and codon usage allowed us to establish correlations between mRNA stability, RSCU, and intracellular protein expression. This study demonstrates that variants and more specifically, synonymous variants can have a substantial and definite effect on ADAMTS13 function and that bioinformatic analysis may allow development of predictive tools to identify variants that will have significant effects on the encoded protein.

No abstract

As demand for e-commerce surged during the COVID-19 pandemic, investors began pouring billions into start-ups promising to accelerate digitization and automation in small-margin, winner-take-all sectors, such as retail, grocery, and dining. I examine two business models that feature prominently in this swell of financial optimism: dark stores and ghost kitchens. Both sacrifice consumer-facing real estate to create logistical spaces for online order fulfillment, and both are predicted to become permanent fixtures of the post-pandemic economic landscape. However, few have commented on the consequences of this future-in-the-making or who is likely to suffer them. The essay therefore anticipates how “going dark” may impact consumers, workers, and urban geographies. I argue that going dark represents a new threshold in the spatial materialities and financial imaginary of platform urbanism, what I call the logistical-urban frontier. I theorize how this frontier threatens historically disenfranchised urban communities, and I conclude the essay with a reflection on the conflicted temporalities of logistical speculation.