Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.

Abstract— An autostereoscopic display based on dual‐directional light guides with a fast‐switching liquid‐crystal panel was designed and fabricated to provide better 3‐D perception with image qualities comparable to that of 2‐D displays. With two identical micro‐grooved light guides, each with a light‐controlled ability in one direction, two restricted viewing cones are formed to project pairs of parallax images to the viewer's respective eyes sequentially. Crosstalk of less than 10% located within ±8°–±30° and an LC response time of 7.1 msec for a 1.8‐in. LCD panel can yield acceptable 3‐D perceptions at viewing distance of 5.6–23 cm. Moreover, 2‐D/3‐D compatibility is provided in this module.

A novel micro‐grooved structure of lightguide and a sequential driving scheme of light sources are proposed to improve image quality of 3D time‐multiplexed mobile display. The distribution of micro‐grooves is modified to suppress the moiré pattern induced by color filter and also achieve directionality and uniformity of greater than 75%. In addition, the driving scheme of lighting up the LEDs in sequence can efficiently reduce the image crosstalk when refreshing images.

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