Background: Hypertensive disorders during pregnancy are the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Raised blood pressure in pregnancy is the major cause of fetomaternal morbidity and mortality. The most important feature in preeclampsia is hypertension which is supposed to be due to vasospastic phenomenon in kidney, uterus, placenta and brain. Altered lipid synthesis leading to decrease in PGI2:TXA2 ratio is also supposed to be an important way of pathogenesis in pregnancy induced hypertension.Methods: This one-year prospective case control study total 200 pregnant women attending antenatal care and admitted in eclampsia ward fulfiling the inclusion criteria were studied. Serum lipid profile was estimated by semiautomatic analyzers. Statistical analysis of data was done by student’s t-test and p-value.Results: Mean total cholesterol in pregnancy induced hypertension was 278.5±52.52 mg/dl and normal pregnancy was 245.47±20.075 mg/dl. Mean triglycerides in pregnancy induced hypertension was 249.88±92.575 mg/dl and normal pregnancy was 206.89±46.345 mg/dl. Mean HDL in pregnancy induced hypertension was 43.69±4.135 mg/dl and normal pregnancy was 49.9±6.501 mg/dl. Mean LDL in pregnancy induced hypertension was 174.43±39.083 mg/ dl and normal pregnancy was 151.22±19.92 mg/dl. Mean VLDL in pregnancy induced hypertension was 46.885±15.143 mg/dl and in normal pregnancy was 40.964±9.061 mg/dl, total cholesterol, low density lipoprotein, very low density lipoprotein, triglycerides were increased in pregnancy induced hypertension when compared to normal pregnancy, which is statistically significant.Conclusions: We concluded that the Patient who developed pre-eclampsia have abnormal lipid profile. This abnormal lipid profile is responsible for endothelial dysfunction. This endothelial dysfunction may play a key role the pathophysiology of pre-eclampsia. Early detection of these parameters may help patient by preventing complications and is going to aid in better management of pre-eclampsia.
with a further interest in drawing up implementable ways to reduce mortality rates in the future. Materials and Methods: This was a retrospective study carried out at Department of Obstetrics and Gynaecology, KNH, IGMC Shimla, HP with the details collected from the patient case sheets and the maternal review death forms from January 2015 to December 2018. Results: There were 42 cases of maternal mortality over a period of 4 years. The MMR of the four years was 162.43. Various causes of death in these 42 patients, according to the WHO-ICD 10 criteria, were hypertensive toxemia 21.40% (n=9), fulminant hepatitis 19.40% (n=8), sepsis 16.60% (n=7), and hemorrhage 11.9% (n=5). Conclusion:The various causes of maternal mortality are either preventable or have highly effective intervention. The four necessary areas in the spectrum of maternal care include a good prenatal care, skilled birth assistance, comprehensive emergency obstetrics care and a good postnatal care.
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