In recent years, carbon-carbon (C-C) bond formation, by directly connecting two different C-H bonds under oxidative conditions, has attracted much attention in academia and industries. Also known as Cross-Dehydrogenative Coupling (CDC), this methodology is an eco-friendly, cost and step economic as well as superior alternative to classical CC coupling reactions. The catalytic functionalization of C-H bonds using
Abstract:In recent years, reactions of inexpensive and easily available formamides, benzaldehydes and cycloalkanes with various coupling partners have made an impact in the field of cross dehydrogenative coupling. Even in the absence of a benzylic C-H site or a heteroatom at the α-position, these sub-
Carbon–carbon and carbon–heteroatom bond construction through oxidative carbon–hydrogen bond activation has attracted much attention in synthetic organic chemistry. Recently, a variety of reactions of inactivated cyclic ethers (THF, THP and dioxane) and acyclic ethers with various coupling partners have been reported. Despite the absence of phenyl rings and high oxidation potentials, these ethers worked efficiently under oxidative conditions. This review focusses on recent reports of C–C and C–heteroatom bond formation in these cyclic and acyclic ethers through cross dehydrogenative coupling.
The development of greener and atom economical methods for carbon-heteroatom (CÀ Het) bond formation is of significant importance in synthetic organic chemistry. In this regard, metal-free cross-dehydrogenative coupling (CDC) represents an attractive approach as it is more facile and environment friendly. This review intends to focus on the recent developments in metal-free CDC reactions for CÀ Het bond formation leading to the synthesis
A simple protocol for the C1 arylation of tetrahydroisoquinolines with aryl Grignard reagents via diethyl azodicarboxylate (DEAD) mediated oxidative C-H activation under metal-free conditions has been developed. The target compounds, including some naturally occurring alkaloids, were obtained in moderate to good yields.
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