Inguinal hernia is one of the commonest pediatric surgical problems and when treated early and appropriately is associated with negligible morbidity and very rarely any mortality. In our prospective study we introduce a new method for repair of hernia in infants, children and adolescences without disruption of external ring. Our study involves 252 patients with inguinal hernia, the ages ranging from 7 days to 15 years, 8 female and the remaining male. We apply the principles of minimal access surgery but without laparoscope that's to say the smallest incision, a short stay in hospital, a rapid recovery, the least cost and fewer complications with no recurrence. So we can say that it is nonlaparoscope minimal access surgery.
The aim of the present study was to investigate the toxicological effects of moxifloxacin in mice to determine the toxicological implications. Forty mice of both sexes were divided into four groups of 10 mice each, designated as A, B, C and D. Group A served as the control and received 2 ml of distilled water, while Groups B, C and D were orally administered 12.5, 25 and 50 mg/kg body weight of moxifloxacin once daily for 7 days, respectively. The weights of the mice were recorded before and throughout the duration of drug administration. Blood samples were collected for serum analysis. Total blood protein, cholesterol, triglyceride, creatinine, activities of aspartate transaminase, alanine transaminase and alkaline phosphatase, levels of high density lipoprotein-cholesterol and low density lipoprotein-cholesterol were assayed. There were significant (P≤0.05) differences in the concentrations of serum creatinine, urea, aspartate transaminase, alanine transaminase and alkaline phosphatase, levels of high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, cholesterol and triglyceride of mice administered moxifloxacin. Serum level of total bilirubin in low dose treated animals was not significantly different from that of the control group animals, but there were significant dose dependent decrease in the animals treated with 25 mg/kg as well as 50 mg/kg. Data of the study indicate there was a dose dependent reduction in the protein metabolites, lipid profile and liver enzyme activities of mice administered moxifloxacin.
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