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A series of 3 nitro 2 trifluoromethyl 2H chromenes was synthesized by the reactions of salicylaldehyde derivatives with 3,3,3 trifluoro 1 nitroprop 1 ene. Further transformations of the synthesized chromenes gave hitherto unknown 3 amino 2 trifluoromethylchromanes prom ising as precursors for the synthesis of fused heterocyclic systems. Cytotoxicity assay first revealed the pronounced activity of several 2 nitro 2 trifluoromethyl 2H chromenes against human tumor cell lines.
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