Screening by maternal factors and biomarkers at 11-13 weeks' gestation can identify a high proportion of pregnancies that develop early and preterm PE. © 2018 Crown copyright. Ultrasound in Obstetrics & Gynecology © 2018 ISUOG.

Assessment of a combination of maternal factors and biomarkers at 11-13 weeks provides effective first-trimester screening for preterm PE. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.

ABSTRACT

The traditional definition of pre-eclampsia (PE), based on the development of hypertension and proteinuria, has been revised to include cases without proteinuria but with evidence of renal, hepatic or hematological dysfunction. The new definitions of PE resulted in, first, an increase in pregnancies classified as having PE but the additional cases had milder disease, and, second, a non-significant decrease in the performance of first-trimester screening for PE. What are the clinical implications of this work? The new definitions of PE will inevitably be adopted by professional organizations and will be incorporated into routine clinical practice. In terms of first-trimester assessment of risk for development of PE, the new definitions of PE would have a minimal impact on the performance of screening.

Objective To define the contribution of maternal variables which influence the measured fetal middle cerebral artery (MCA)