The preparation of 75Se‐ebselen (75Se‐PZ 51) in a high radiochemical yield (∼40 %) and with a specific activity of 240 mCi/mM (8.9 GBq/mM) is described. It entails a very simple, fast and one‐pot procedure starting from elemental 75Se‐selenium.
75Se‐diselenosalicylic acid 4 is initially prepared as the key intermediate which is transformed into a corresponding dichloride 5‐before reacting with aniline to yield the desired 75Se‐ebselen.
Identity and purity of the labelled compound were controlled by comparison in TLC, HPLC and MS with an authentic sample (1‐2).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.