146 Understanding the pulmonary circulation stable on calcium channel blocker therapy for at least 1 year. The following cardiovascular (CV) risk factors were assessed: lipid profile, serum glucose level, presence of diabetes, hypertension and smoking status. The association between level of HDL-C and results of the VR testing were adjusted for CV risk factors and established markers of IPAH severity: World Health Organization functional class (WHO-FC), 6-minute walk distance (6-MWD), N-terminal pro-brain natriuretic peptide (NT-proBNP) serum level, cardiac index (CI), right atrial pressure (RAP) and pulmonary vascular resistance (PVR). Results: We enrolled 66 IPAH patients, treatment-naive at baseline, aged 49.4±17 years (43 females): 9 long-term responders and 57 non-responders in WHO-FC II-IV. HDL-C level was correlated with greater drop of mPAP during VR testing (r=0.32; p=0.009) and this association remained significant after adjustment for IPAH severity markers and CV risk factors (R2=0.23; p=0.002). Patients classified as long-term responders were characterized by higher baseline HDL-C concentration than non-responders (1.75±0.27 vs. 1.14±0.34mmol/l; p<0.001). Non-responders presented with more severe disease defined by higher WHO-FC (3.0±0.5 vs. 2.5±0.5; p=0.009), NT-proBNP level (2266±3726 vs. 547±1035pg/mL; p=0.004), RAP (8.5±5.5 vs. 4 Research Institute of Phthysiopulmonology, Chisinau, Moldova Republic ofThe aim of this study was to investigate the relationship between polymorphism of angiotensin-converting enzyme (ACE), pulmonary hypertension and the right ventricle parameters in patients with chronic obstructive pulmonary disease (COPD). Materials and methods:The study was performed on 127 patients (124 males and 3 females) with different severity grades of COPD, aged between 22 and 60 years (mean age 55,7±0,74 years). All patients satisfied the GOLD criteria for COPD. Pulmonary function tests, blood gases, bodyplethysmography, diffusing capacity for CO, ECG, Doppler EcoCG had been performed in all patients. This data was analysed depending on the revealed genotype. Genomic DNA was extracted from peripheral blood leucocytes by standard methods while the ACE genotypes of all subjects were determined by polymerase chain reaction. Concomitant left ventricular dysfunction was excluded in all patients by echocardiography. Results: The obtained data revealed prevalence of patients with ID genotype (44,1%) in comparison with DD and II genotypes (28,3% and 27,6%, respectively). The highest values of mean pulmonary artery pressure (mPAP) were observed in patients with ID genotype (32,4±2,75 mmHg, p<0,05) vs. 26,8±3,63 mmHg and 25,7±2,72 mmHg in II and DD genotypes, respectively). The right ventricle (RV) end-diastolic diameter was significantly increased in patients with DD genotype (30,4±2,75 mm, p<0,05) vs. patients with II and ID genotypes (25,7±2,42 mmHg and 24,3±3,15 mmHg, respectively). There was no observed relationship between ACE gene genotypes and right and left ventricle hypertrophy, left ventri...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.