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Certain aspects of cardiovascular function were studied in dogs that were cooled to 30 C. without ventilatory assistance, and rapidly rewarmed in warm water. While in the hypothermic state, the animals appeared to make an adequate cardiovascular adjustment to the lowered body temperature. Upon rewarming, however, each animal incurred an acute circulatory collapse, which was characterized by a low cardiac output, diminished ventricular work, hypotension, hyperpnea, and increased arteriovenous oxygen difference. It is uncertain whether this circulatory failure is central or peripheral in origin.

The individud variations of blood sugar (solid kin-) and serum inorganic phosphorus (dotted lines) from the initial values during the diffea-ent perids of the experiment.tion of glucose alone( 18) that occurs under the influence of ACTH is not due to a deficiency in insulin production. It was passible to observe that the changes of blood sugar tended to appear and disappear sooner than its mechanism although closely related phenomena. It may be that these experiments could be interpreted as an in vivo reduction of the rate of phosphorylization induced by adreno-cortical stimulation.