Today, less attention has been paid to x-ray studies of animals in connection with the advent of more modern methods. At the same time, the quality of radiopaque substances decreased, which is reflected in this article. The Omnipack, Urografin, Visipack, Barium sulfate, Iodipamide, Bilignost and Biligrafin used in radiopaque contrast studies in most cases did not reveal the hepatobiliary system. Only the last two drugs gave satisfactory results. The complexity of the X-ray examination of the biliary system in cats and dogs lies in the features of the location of the extrahepatic bile ducts and the condition of the intestine, the size of the liver, its structure, echogenicity, the state of the vessels and surrounding organs. In this work, we took into account the anatomical variants of the development and location of organs in animals, which may complicate the study or evaluation of the data obtained. These included changes in the contours, shape, location of the gallbladder and its filling. The results obtained were compared with the available general species standards, taking into account the possible individual characteristics of each animal. Other studied drugs gave satisfactory results with an overall assessment of the abdominal organs, but we preferred Omnipack. Survey radiography provides a large amount of information with the correct selection of radiopaque substances.
The article presents the results of the elaboration of techniques for identification and assay of a new active pharmaceutical substance (API) – 3- (1H-benzimidazol-2-yl) -1,2,2-trimethylcyclopentane-carboxylic acid. To identify the API, the method of IR spectroscopy was used, the assay was carried out using the method of direct acidimetric titration in a medium of glacial acetic acid. Methods were validated in accordance with the requirements of the State Pharmacopoeia of the Russian Federation and are suitable for further use in quality control in the production of 3- (1H-benzimidazol-2-yl) -1,2,2-trimethylcyclopentane-carboxylic acid.
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