Reactions of primary and secondary amines with methyl diazoacetate in the presence of Ru 2 (OAc) 4 Cl gave the corresponding N-substituted glycine methyl esters in almost quantitative yield. Catalytic decomposition of methyl diazoacetate generates methoxycarbonylcarbene which is inserted into the N-H bond of amines with high regioselectivity.
Reaction of Methyl Diazoacetate with Amines Catalyzed by Ru 2 (OAc) 4 Cl. -Ru2(OAc)4Cl is an efficient catalyst for the reaction of primary and secondary amines with methyl diazoacetate leading regioselectively to N-substituted glycine methyl esters. -(MAIDANOVA, A. V.; BAKEEVA, A. D.; SULTANOVA, R. M.; BIGLOVA, R. Z.; DOKICHEV*, V. A.; Russ.
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