According to statistics, every fifth married couple has problems with pregnancy. It is known that among all the factors of infertility, the first place is occupied by the tubal-peritoneal factor, and the most common cause of non-pregnancy is a violation of the receptive ability of the endometrium. In the study of the endometrium in patients with unsuccessful attempts at assisted reproductive technologies and severe endometrial insufficiency, there are changes in receptivity, impaired development of foaming, decreased expression of implantation molecules. The development of new methods for correcting the receptive function of the endometrium remains an important step. It should be noted that currently there are no standardized approaches to pre-pregnancy preparation of endometrial receptivity with pronounced signs of lag. Also today, special attention is paid to the impact of carbohydrate metabolism disorders on women's reproductive health. Based on the analysis of literature data and the results of their own retrospective observations, the team of authors identified the role of disorders of carbohydrate metabolism and autoimmunization with food allergens in the violation of endometrial receptivity. It is noted that severe endometrial insufficiency is significantly correlated with an increase in the number of women with disorders of carbohydrate metabolism. The initial algorithm of preliminary preparation of the endometrium of normal immune systems and carbohydrate conversion of heirs in accordance with the mode of processing and analysis is developed and offered. Created, adherence to the elimination diet increases the receptivity of the endometrium with a collection of women according to standard schemes. The proposed training algorithm also improves the overall health of patients, reduces metabolic manifestations.The results of the studies indicate the need for a differentiated approach to the correction of endometrial receptivity and pre-pregnancy preparation of the endometrium before subsequent cycles of ART.
Obstetricians-gynecologists do not always pay sufficient attention to nausea and vomiting of pregnancy (NVP), sometimes its severity is underestimated and adequate treatment is not prescribed. The objective: to investigate the efficacy and safety of the complex therapy of NVP in pregnant women after ART, including a preparation of ginger extract with pyridoxine and psychotherapy. Materials and methods. Sixty pregnant women were examined after applying VRT, with mild manifestations of NVP. The main group consisted of 30 women, with Emegest (ginger and pyridoxine extract) and psychotherapy used in NVP therapy, and a comparison group of 30 women who only adhered to recommendations on changes in diet and life. The presence of the syndrome of autonomic dysfunction was established using the A.M.Veyn questionnaire. For self-assessment of the level of reactive and personal anxiety, testing was carried out according to the method of Ch.D. Spilberger, Yu.L. Khanin. The quality of life was assessed using the SF-36 questionnaire. Results. The use of recommended NVP therapy in pregnant women after ART makes it possible to improve the condition of women already for 2–3 days, and in 2 weeks of treatment it is essential to reduce or even eliminate the symptoms of NVP. Complex therapy reduces the severity of the syndrome of autonomic dysfunction and the level of personal and situational anxiety, which, against the background of improving the overall condition, positively affects the quality of life. The applied therapy had no side effects or complications, positively influenced the further course of pregnancy and the condition of the fetus and the newborn, in particular, the frequency of preeclampsia is decreased by half and the birth asphyxia by 1.5. Conclusion. The safety and efficacy of Emegest in the complex therapy of nausea and vomiting of pregnancy allows us to recommend its use in pregnant women after ART. Key words: nausea and vomiting of pregnancy, Emegest, auxiliary reproductive technologies, psychotherapy.
The features of thermal methods for the determination of kinetic parameters of oxidation of carbon materials are considered in the article. A modified method for the determination of kinetic parameters on the basis of the quantities characterizing the steady state of a system is suggested.
Reproductology is one of the most dynamically developing branches of modern medical science. It becomes especially important in the context of changes of recent years in society, the main of which is the postponement of childbirth compared to previous generations. In addition, such an important and multifactorial problem as infertility encourages scientists to find different ways to overcome it, taking into account the number of etiological factors and different initial reproductive potential of each member of the couple. In vitro fertilization (IVF) can comprehensively solve the problem, as the procedure involves the reconstruction of the process of fertilization under the supervision of the specialist, «bypassing» the critical points that are often affected by pathological processes in male or female organism. One of the main parameters that determines the prospects of using of these assisted reproductive technologies and, in fact, the strategy of IVF cycles, is ovarian reserve, which characterizes the functional ability of the ovary to generate a follicle independently / in response to exogenous influences. In recent decades, many methods have been proposed to assess it and to predict the so-called poor, «bad» ovarian response to stimulation. It goes in accordance with the fact that for patients with reduced ovarian reserve, it is advisable to use adapted schemes of controlled ovarian hyperstimulation (COH), which takes into account the main pathophysiological properties of folliculogenesis in this category of women. Numerous studies show different data on the effectiveness of gonadotropic hormones (gonadotropins, HT) of different origin in women with different ovarian reserve. This article highlights modern ideas about controlled ovarian hyperstimulation using gonadotropic hormones of various origins, demonstrates the main clinical aspects of implementation of available markers of reduced ovarian reserve, analyzes data on the effectiveness of administration of gonadotropin of different origin in patients with different ovarian reserve and possible measures to increase the efficiency of IVF cycles in patients with reduced ovarian reserve. Keywords: in vitro fertilization, controlled ovarian hyperstimulation, ovarian reserve, gonadotropins.
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