Keywords: N-methylmorpholinium 1-amino-2,4-dicyano-4-ethoxycarbonyl-1,3-butadienethiolate, pyrido-[1,2-a][1,3,5]triazines, cascade heterocyclization, Mannich reaction, X-ray structural analysis.It is known from numerous literature data that the three-component Mannich cyclocondensation of a series of mercaptoazoles and -azines, formaldehyde, and primary amines serves as a convenient method of obtaining various heterocyclic systems annelated with the 1,3,5-thiadiazine ring [2][3][4][5][6][7][8][9][10][11]. Recently heterocyclization of a similar type was used successfully by us to obtain derivatives of pyrido-[2,1-b][1,3,5]thiadiazine [12,13]. Continuing investigations of polycomponent cascade reactions [14], we turned our attention to N-methylmorpholinium 1-amino-2,4-dicyano-4-ethoxycarbonyl-1,3-butadienethiolate (1) [15] as a promising subject for carrying out cascade heterocyclization under the conditions of the Mannich reaction. This diene is readily available and fairly stable. Even on boiling for 3 h it crystallizes out from _______ * For Part 2 see [1].
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