Currently, various amino bisphosphonates are widely used in the treatment of many bone diseases. One of the most well-known complex compounds of neridronic acid (6-amino-1-hydroxyhexylidene-1,1- bisphosphonic acid) is sodium neridronate – a bisphosphonate, which is used to treat osteogenesis and Paget's disease. However, there is no data on compounds of neridronic acid with rare earth elements. A new complex of lanthanum with 6-amino-1-hydroxyhexylidene-1,1-bisphosphonic acid (I) was obtained and characterized by various physicochemical methods (chemical analysis, IR spectroscopy, solid-phase 31P NMR spectroscopy, optical microscopy, PCA, DTA). According to the research data the complex I has the composition {La[(H3N-(CH2)5-C(OH)(PO2(OH))2]2(H2O)2}[OH]·H2O and represents the coordination 1D-polymer due to two bridged phosphonic groups with lanthanum atoms in a tetragonal-antiprismatic environment. In a crystal, polymer chains form a 3D-frame porous structure by means of strong hydrogen bonds O─H ··· O and N─H ··· O with endless channels, available to include a variety of inorganic anions or small organic molecules. A study under the microscope showed that the sample is needle crystals (thin rods) of different lengths. The particle size distribution was obtained by laser diffraction, and the average particle size was determined: 50 µm in length and 2.5 µm in thickness.
It is interesting in chemical terms and promising in the applied production of new complexes of metals with bisphosphonic ligands with a popular set of consumer properties. To date, little has been studied chemistry of bisphosphonic acid complexes with the basic structure of 1-hydroxymethylene-bisphosphonic acid with a side chain containing 11 carbon atoms and ending with an amino group. The main objective is to obtain new bisphosphonates of s-, p -, d - and f-elements, their characterization by a complex of physical and chemical research methods (NMR and IR spectrometry, RSA, DTA, optical microscopy, laser diffraction) and to identify new applications of bisphosphonic acids and their salts. In the course of the work, complexes of Ag, Pb, Ca, with 1-hydroxymethylene-bisphosphonic acid (H2N(CH2)xC(OH)(H2PO3)2) and its derivatives, the side chain ends with an amino group, its length is 11 carbon atoms. Crystal structures of metal-bisphosphonate complexes with the general formula H2N(CH2)10C(OH)(HPO3)xM (M = Ag, Pb, Ca) were determined. The complexes were characterized by IR spectroscopy and 31P solid-state NMR spectroscopy, RSA. The areas of practical use of the complexes are outlined. It is shown, by the example of wastewater in Kuopio, Finland, that bisphosphonic acids can be used for wastewater treatment of enterprises from heavy metals (M =Pb, Zn, Cd, etc.).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.