Objective: The present investigation focus on screening of phytochemicals and FT-IR analysis of Myristica dactyloids fruit extracts. The fruit extracts were prepared using five different solvents. Methods:The phytochemical analysis and FT-IR (Fourier transform infrared spectroscopy) analysis were performed using standard methods. Results:The results reveals that the alkaloids, steroids, flavonoids, phenolic compounds, proteins, carbohydrates, cardio glycosides and saponins were present in methanolic extract when compared to other solvent extracts. FT-IR analysis shows the presence of different functional groups such as carboxylic acids, aromatics, alkanes, alcohols, phenols, aliphatic amines, alkenes and amine groups in the fruit extracts. Conclusion:The study concluded that the methanolic extract (M. dactyloides fruit) has potential bioactive compounds.

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Objective: The objective of present research work was to formulate and evaluate a novel oral edible gel dosage form using gellan gum as gelling agent and carvedilol as a model drug to ease the administration to dysphagic and geriatric patients. Methods:Oral edible gels were prepared using gelling agent low acetylated gellan gum and sodium citrate in different concentrations. The prepared edible gel formulations were evaluated for gelation time, appearance, texture, viscosity, pH, syneresis, drug-excipient compatibility studies by fourier transform infrared FTIR and percentage of drug release from the gel formulation.Results: Formulation containing gellan gum (0.4 % w/v) and sodium citrate (0.3 % w/v)) was found to be "spoon thick" in consistency that is accepted for dysphagic patients as per national dysphagia diet task force. This formulation showed more than 95 % drug release within 12 min and found to be stable for 6 mo. All other parameters tested were optimal. Hence, this formulation was considered optimized. Conclusion:From this study, it can be concluded that the novel edible gel dosage form containing Carvedilol can be formulated and this dosage form may prove to be more efficacious in the treatment of hypertension in dysphagic patients.