Summary
A patient with congenital agammaglobulinaemia received I.M. commercial gammaglobulin for therapeutic purposes which produced cyanosis, unconsciousness and a momentarily impalpable pulse. There was no evidence of humoral antibody against IgG or IgA. There was no evidence of detectable IgE in this patient. Lymphocyte transformation suggests that delayed type hypersensitivity to exogenous gammaglobulin did not exist. Abnormal histamine release on exposure of washed leucocytes to IgG aggregates was demonstrated. It is likely that this anaphylactoid reaction and other evidences of hypersensitivity to exogenous gamma globulin was mediated through interaction between complement and gamma globulin aggregates and that an active immune response to the gamma globulin was not involved.
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