Women aged !18 years diagnosed with AEC (initial diagnosis: stage III/IV, or early stage with subsequent locoregional/distal recurrence) between 1 January 2013 and 30 September 2020, inclusive, were eligible provided they received platinum-based chemotherapy at any time following diagnosis and had !2 clinical visits. Patients were followed up from initiation of systemic treatment for recurrent/metastatic disease after advanced diagnosis until 31 March 2021, last available follow-up, or death (whichever occurred first). Overall survival (OS) and time to first subsequent therapy or death (TFST) were estimated with Kaplan-Meier methodology. Result(s)* Overall, 2202 women with AEC were included; most (82.7%) were treated in a community setting and presented with stage III/IV disease at initial diagnosis (74.0%; table 1). Compared with other subtypes, a higher proportion (26.3%) of women with USC were Black/African American. Thirty-three (1.5%) patients did not have recorded therapy following AEC diagnosis. The most common first systemic treatments for recurrent/metastatic disease were platinumbased combination chemotherapy (82.0%), platinum-based single-agent chemotherapy (7.9%), and platinum-based chemotherapy plus HER2-targeted therapy (2.9%); median (interquartile range) duration was 9.2 (4.1-23.2) months. Median (95% confidence interval [CI]) OS from initiation of first systemic treatment was shorter in patients with USC (31.3 [27.7-34.3] months), .0] months), and carcinosarcoma (14.4 [7.9-53.1] months) versus the overall population (49.6 [43.9-52.0] months; table 2), as was median TFST from initiation of first systemic treatment (table 2). Conclusion* In this large real-world study, patients with advanced USC, CCC, and carcinosarcoma had poorer survival outcomes than the overall AEC population, demonstrating an unmet need in these populations, such as the requirement for more effective therapies.
Background:Reductions in the dose intensity (DI) of adjuvant anthracycline-based chemotherapy in early stage breast cancer are frequently required due to treatment toxicity or poor tolerance, but the implications of a minimal reduction in DI on clinical outcome remain uncertain.Patients and methods:Women with stage I–II breast cancer treated with adjuvant adriamycin and cyclophosphamide (AC) from 1990–95 were identified in a provincial breast cancer database. Cases were classified into four cohorts: (1) all cycles delivered at full dose and on time; (2) one single dose reduction or dose delay; (3) >1 dose reduction or dose delay; (4) <2 cycles of chemotherapy delivered.Results:484 eligible cases were identified (cohort (1): n = 268; (2): n= 88; (3): n= 89; (4) n= 39). Slight imbalances in lymph node status (p=0.05) and adjuvant hormonal therapy (p=0.05) were observed between the cohorts. Fifty-five per cent (267/484) of the patients had node-positive disease and 33% (158/484) were ER+. 45% of cases had a reduction in DI. With a median follow-up of 9.6 years, there were no significant differences in relapse-free survival (p=0.94), breast cancer-specific survival (p=0.87) or overall survival (p=0.86) between the four cohorts. Outcomes were independent of hormone receptor status.Conclusions:Although toxicity related reductions in the DI of adjuvant AC chemotherapy for early stage breast cancer are common, they did not appear to significantly impact on clinical outcomes in this population-based cohort of women with stage I–II breast cancers.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.