Rh iso-immunisation is prevalent in many underdeveloped countries. Severe haemolytic anaemia with or without hydrops fetalis, dangerous level of haemolytic unconjugated bilirubin and imminent bilirubin encephalopathy are the hallmarks of haemolytic disease of the newborn. The investigative protocols and efficient management of this entity are adequately described in literature. An unusual manifestation of this disease with severe hepatocellular damage and conjugated hyperbilirubinemia was noticed in a neonate. The literature has been reviewed and the specific symptom complex has been attributed to 'syndrome of hepatocellular damage', which is a rare accompaniment of haemolytic disease of the newborn. Attempts have been made to describe the syndrome in detail, with latest reference regarding complete workup and management. Few useful tips for prevention of the disease in a community background have been suggested.
Myelofibrosis (MF), or fibrosis of the bone marrow, is an uncommon condition in children. Fewer than 100 cases have been described in the medical literature. Most cases in children arise secondary to other disease processes. We present a case of Myelofibrosis in a 12-year-old girl. The purpose of reporting this case is that this child had a diagnostic dilemma and was sent home with poor prognosis but with proper diagnosis and treatment she improved and may have a complete cure, as the myelofibrosis was secondary to tuberculosis.
Wheeze associated respiratory infection is an important cause of morbidity andmortality in both the developed and the developing worlds. The commonest causativeagent is the Respiratory Syncytial Virus (RSV). Lower respiratory infection with thisvirus is assuming great proportions and hence much work is being done to find a cureor at least a suitable vaccine that will be available to everyone even in the poorercountries. This article reviews the latest literature and attempts to set out someguidelines to help inreduction of the problems associated with lower respiratoryinfection caused by RSV in developing countries.Key Words : Lower respiratory infection, Respiratory Syncytial Virus.
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