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As lipid peroxidation and oxidative stress play a key role in the pathogenesis of diabetes, the antioxidant status of streptozotocin induced diabetic rats, treated with vanadium complex was explored in the present study. Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ) at the dose rate of 45 mg per kg body weight. Diabetes was confirmed after 72 hours of STZ injection by estimating blood glucose level and those rats showing more than 250 mg/ dL were considered as diabetic. Vanadium complex at the dose rates of 5 and 10 mg / kg body weight was administered orally to normal control and STZ induced diabetic rats. Glimepiride was used as the positive control and was given orally at the dose rate of 800 μg / Kg body weight. The study on the hepatic, renal and pancreatic tissues showed that vanadium complex at both the predetermined dosages significantly increased the antioxidant activities of superoxide dismutase and glutathione peroxidase along with a significant increase in the level of glutathione and a significant decrease in the level of lipid peroxidation. The study also revealed that there is a significant reduction in the activity of catalase after treatment with vanadium complex at both the dosage levels.

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AIM OF STUDY:To study the clinical presentation, course, complications and outcome of scorpion sting envenomation. To establish the usefulness of prazosin therapy and to emphasize that shorter the sting-prazosin interval, better the outcome. DESIGN: Observational. SETTING: Tertiary Care Hospital in Trichy, Tamilnadu. PARTICIPANTS: 60 children aged 1 to 12 yrs., with Scorpion envenomnation. MATERIALS AND METHODS: Prospective study of 60 children with Scorpion sting admitted at Mahatma Gandhi Memorial Government Hospital, Trichy from July 2013 to August 2014. The severity of Scorpion sting was graded on admission into three (3) categories and the outcome evaluated. RESULTS: 66.66% of children were admitted with autonomic storm. Majority of children 43.33% had Grade II severity. 48.33% received 1 st dose prazosin within 4 hours of sting, 45% received prazosin between 4-8 hrs. 6.66% of children received 1 st dose of prazosin after 10 hours of sting due to delayed referral. The mean time of reversal of autonomic storm was between 6-24 hrs. CONCLUSION: The present study emphasizes the beneficial effects of Prazosin therapy in scorpion envenomnation. The time lapse between sting and administration of prazosin greatly influences the outcome of these children.

Background: This study is conducted at Mahatma Gandhi memorial hospital, Trichy gains significance as there hasn‘t been any of its kind prior to this among children and in this geographical area. Aim and objectives of the study were to study the clinical profile of children presenting with febrile thrombocytopenia and possible etiology. The study correlates clinical features with the laboratory parameters and assessing the complications associated with fever and thrombocytopenia.Methods: Prospective, descriptive study consist of 200 children aged 1 months to 12 years admitted with fever and thrombocytopenia as inpatients in the paediatric wards at Mahatma Gandhi memorial government hospital, Trichy during July 2017 to June 2018. Inclusion criteria included children aged 1 month to 12 years admitted in paediatric wards of MGM GH, Trichy, exclusion criteria excluded neonates <1 month and children >12 years, patients presenting with thrombocytopenia without fever, ITP, platelet dysfunction disorders, malignancy, patients on chemotherapy and immunosuppressive agents and on drugs causing thrombocytopenia. Results: Dengue was the most common cause of febrile thrombocytopenia in our region accounting for 56% of cases, this is followed by enteric fever in 17%, undifferentiated fever in 16.5%, sepsis in 6.5%, scrub typhus in 3.5% and malaria in 0.5%. 5% of children with febrile thrombocytopenia were given platelet transfusion. 95% (n=190) of the children with febrile thrombocytopenia improved and were discharged. 1% (n=2) left against medical advice. The mortality rate in the study is 4% (n=8).Conclusions: The risk of bleeding increases as the platelet count decreases. The mortality is not related to the severity of thrombocytopenia.

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Background: The aim of the study was to find out the neurodevelopmental outcome of babies with hypoxic ischemic encephalopathy at 6 months of age and to predict early markers of abnormal neurological outcome in those babies.Methods: 50 babies admitted with hypoxic ischemic encephalopathy were enrolled in this prospective study and followed up at 3 and 6 months of age at Mahatma Gandhi Memorial Government Hospital, Trichy. The neurological outcome of the babies was assessed by CDC grading of motor milestones, Trivandrum development screening chart, Amiel Tison angles head circumference and weight measured. USG cranium was done for all the babies and MRI brain was done in babies with abnormal neuro sonogram and abnormal outcome. Vision and hearing were tested clinically.Results: The incidence of abnormal neurological outcome was 14%. The early markers predicting abnormal neurological sequele are identified.Conclusions: Early identification of abnormal neuro behaviour helps in starting early intervention to improve the long term outcome.