Background: Nephrotic Syndrome is one of the most common glomerular disorders of childhood. Relapse rate after steroid discontinuation is 39-59%. Hyperlipidemia is one of the cardinal features in patients with Nephrotic Syndrome. Cases with increased serum levels of cholesterol and LDL have also been reported even after months or years in remission. The persistent hyperlipidemia correlates well with the duration and frequency of the relapses, even during the remission. Aim: To study the correlation between remission phase hyperlipidemia and subsequent relapse in Nephrotic Syndrome. Methods: Sixty five children were included in this cohort study at Kanyakumari Medical College & Hospital, Asaripallam. Fasting lipid profile is estimated at the acute phase of Nephrotic Syndrome before starting steroid therapy and 10 weeks after remission. They were followed up for six months from the time of remission to determine the occurrence of relapse. Results: Among the 60 included patients, 22 cases had their first episodes and 38 were infrequent relapse. Persistent hypercholesterolemia was observed in ten cases, out of which, seven cases developed relapse. Also, persistent hypertriglyceridemia was seen in 34 cases, out of which, 19 cases developed relapse. However, in the remission phase, hypercholesterolemia (chi sq= 5.090, p=0.024) and hypertriglyceridemia (chi sq= 10.22, p=0.001) were significantly associated with relapse. Conclusion: The role of dietary management and anti-triglyceridemic drugs to prevent progressive renal injury and subsequent relapse in this subgroup of patients' needs to be evaluated.
Background: Growth hormone is the important hormone controlling growth from birth to adolescence. Children with growth hormone deficiency usually present with severe short stature and correct diagnosis by provocative GH test is essential so as to treat such children with costly GH available now. Aim: To study the clinical profile, Anthropometric measurements, Growth Hormone dynamics, Thyroid functions test in short stature children. Methods: Children with height 2 standard deviation below the mean for the age (WHO Growth Charts up to 5 years and Agarwal DK et al growth reference after 5 years) and Children referred to short stature as the primary complaint were included in the study. Anthropometric measurements, clinical examination, dynamic clonidine provocative GH tests were done. Results: Out of 30 short children, 25 children (83%) were identified as having growth hormone deficiency as evidenced by subnormal growth hormone response (peak GH below 10ng/ml). 4 children (13%) were identified as having GH insensitivity (or) Laron's dwarfism in the form of supra-physiological level of serum GH. One child showed normal GH response. Among 25 children who showed GHD 3 of them also showed clinical hypothyroidism as evidenced by the rise of serum TSH level above 5.5 units/ml. Conclusion: Growth hormone abnormality was found to be the most common cause for pathological short stature (96%) when chronic systemic disorders were excluded.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.