Melanoma is the most deadly form of skin cancer of melanocytic origin. The tumor has a high malignant potential and early metastasis. Prognosis is directly linked to the stage of the disease. Diagnosing thin melanoma at an early stage offers patients their best chance for survival. The crucial innovation in the early recognition of melanoma was the development of in vivo examination of the skin in high-resolution, by confocal microscopy. Confocal microscopy and its modifications provides a “virtual biopsy“, owing to melanosomes and melanin, which are a source of endogenous contrast. Confocal scanning laser microscopy (CSLM) provides visualization of microanatomical structures and cellular detail in real time (pigmented keratinocytes, melanocytes, melanosomes and melanophages) in the epidermis, dermoepidermal junction and superficial dermis at a resolution equivalent to the resolution of conventional microscopes. [Projekat Ministarstva nauke Republike Srbije, br. 41002
Introducion. This type of hepatocellular carcinoma is characterized by fever
and persistent leukocytosis. Case report. This is a report of a patient with
a long term fever accompanied by persistent leukocytosis. Abdominal
ultrasonography revealed a focal lesion in the left hepatic lobe, whereas,
computed tomography/magnetic resonance imaging findings were consistent with
a liver abscess. The patient received therapy for liver abscess, without
improvement. He underwent left lobe segmentectomy 3, with histological
features of hepatocellular carcinoma (pseudoglandular type). Conclusion. In
patients with focal hepatic lesions accompanied with raised temeparature and
persistent leukocytosis, without adequate therapeutic response, this
clinicopathological type of hepatocellular carcinoma should be considered.
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