We performed a study of the LiZn excimer formed in the photochemical reaction of Li2(C 1Πu) with Zn(4 1S0). The Li2(C 1Πu) molecules were prepared by excitation with either a dye laser in the region from 348 to 377 nm or an excimer laser at 308 nm. We observed bound–free emission of LiZn at 477 nm. Nonrelativistic ab initio calculations of the potential energy curves and the relevant dipole transition moments have been performed. Using these results in spectral simulations the observed emission is interpreted as belonging to the 2 2Π–X 2Σ+ transition of the LiZn molecule.
A detailed ophthalmological study on 72 individuals at risk to develop Leber's Optic Neuropathy (L.O.N) has revealed that early signs may be present. These included usually non-specific signs such as tortuosity of the peripapillary capillaries as best seen on fluorescein angiography; hyperaemia and a hazy boundary of the disc; relative paracentral and central scotomata; abnormal VERs; and increases in the error score with the Farnsworth 100-Hue test. The only possibly specific sign may be tortuosity of the capillaries. This conclusion was reached by comparing the findings in individuals at risk with the results of examination of five patients seen during the acute phase of L.O.N. One of the persons at risk, who had many early signs, developed L.O.N. 6 months after being studied. In 7 of 13 carriers abnormalities were observed that resembled those seen in certain individuals at risk.
Neurological investigations, HLA-typing and viral antibody studies were performed in patients with Leber's optic neuropathy (LON), in individuals at risk to develop the disease, in obligatory (female) carriers of the disease, and compared with controls. The only relevant findings were an excess of minor neurological abnormalities in patients with LON and in some individuals from the at risk group. Occasionally, an association of LON and a multiple sclerosis-like picture was observed.
Fluorescein angiography was performed in 71 persons at risk to develop Leber's Optic Neuropathy (L.O.N.), in 10 females carriers of this disease and in 5 patients during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 patients could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same fluorescein angiographic abnormalities. One man from the at risk group who obtained high abnormal scores-identical to patients in the acute phase-developed L.O.N. 6 months later.
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