The efficacy and acceptability of nebivolol 5 mg and response rate (70% vs 55%; P ‫؍‬ 0.002). The trough-topeak sitting diastolic ratios also favoured nebivolol enalapril 10 mg, each given once daily, were compared in essential hypertension in a multicentre, randomised, (84% vs 60%, P ‫؍‬ 0.002). Nebivolol, but not enalapril, slightly but significantly lowered heart rate. Both drugs double-blind trial over 3 months. For the index predeclared variable, sitting diastolic pressure at trough were well-tolerated, although enalapril was accompanied by a significantly higher incidence of drug level, nebivolol achieved greater falls in pressure (؊12.3 vs ؊9.9 mm Hg; P ‫؍‬ 0.009) and a higher coughing.

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