Sacoglottis gabonensis (Baillon) Urb. (Humiriaceae) is used as a palm wine additive in Nigeria. When a saline extract was administered to rats at i.p. doses of 125 and 250 mg/kg body weight, serum enzymes indicative of liver damage were elavated in a dosedependant manner. Histological examination of the livers of the treated animals showed mild sinusoidal dilatation and early necrosis (125 mg/kg) or moderate sinusoidal dilatation and congestion with focal hepatocyte necrosis (250 mg/kg). These results showed that the bark extract of Sacoglottis gabonensis is hepatotoxic.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.