Our laboratory started research on tetraazaporphyrins in the middle of the 1970s. Before our works there was no information in the literature about coordination and ionization properties of these compounds, formation of their metal complexes or their state and behavior in proton-donating and proton-acceptor media. We carried out the first studies of the coordination and acid-base properties of unsubstituted tetraazaporphine [1], its octaphenyl [2] and tetra(tetramethylene)-[3] substituted derivatives. In this micro-review we summarize our works on the peripheral functionalization of unsubstituted porphyrazines and on their acid-base and coordination properties.
The pandemic infectious disease (Covid-19) caused by the coronavirus (SARS-CoV2) is spreading rapidly around the world. Covid-19 does an irreparable harm to the health and life of people. It also has a negative financial impact on the economies of most countries of the world. In this regard, the issue of creating drugs aimed at combating this disease is especially acute. In this work, molecular docking was used to study the docking of 23 compounds with QRF3a SARS-CoV2. The performed in silico modeling made it possible to identify leading compounds capable of exerting a potential inhibitory and virucidal effect. The leading compounds include chlorin (a drug used in PDT), iron(III)protoporphyrin (endogenous porphyrin), and tetraanthraquinone porphyrazine (an exogenous substance). Having taken into consideration the localization of ligands in the QRF3a SARS-CoV2, we have made an assumption about their influence on the pathogenesis of Covid-19. The interaction of chlorin, iron(III)protoporphyrin and protoporphyrin with the viral protein ORF3a were studied by fluorescence and UV–Vis spectroscopy. The obtained experimental results confirm the data of molecular docking. The results showed that a viral protein binds to endogenous porphyrins and chlorins, moreover, chlorin is a competitive ligand for endogenous porphyrins. Chlorin should be considered as a promising drug for repurposing.
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