Республиканская детская клиническая больница им. Е. п. Глинки, Грозный, Российская Федерация 2 Ставропольский государственный медицинский университет, Российская Федерация 3 Краевая детская клиническая больница, Ставрополь, Российская Федерация polYmorphic marKers of innaTe immuniTY recepTor genes in neWBorns WiTh hYpoXic-ischemic cns Damage idrisova a. s. 1 , Barycheva l. Yu. 2 , Kuzmina e. s. 2 , mezhidov K. s. 1 , agranovich o. V. 2 , golubeva m. V. 1 1 e. p. glinka republican children's clinical hospital, grozny, russian federation 2 stavropol state medical university, russian federation 3 children's regional clinical hospital, stavropol, russian federation
Relevance. Hypoxic-ischemic damage to the central nervous system is accompanied by overproduction of pro-inflammatory interleukins in newborns. Perinatal inflammatory responses contribute to unfavorable outcomes.
Methods of investigation. The analysis of the cytokine profile in the blood serum was performed in 45 full-term newborns by the method of enzyme-linked immunosorbent assay within 4–96 hours after birth. 32 children had the signs of HIE stage 2, 13 children — HIE stage 3. Unfavorable neurological consequences were formed in 47,4% of children.
Research results. Revealed an increase in the levels of IL1β — 17,7 [13,6; 25,4] and IL6 35,2 [24,9; 45,0] in newborns with HIE. A significant increase in pro-inflammatory cytokines was found in patients with unfavorable outcomes compared with favorable ones. When predicting the disabling consequences of DIE, a high predictive value was established for IL1β and IL6.
Conclusion. In newborns with hypoxic-ischemic encephalopathy, an increase in serum IL1β and IL6 is observed. It is advisable to use an increase in IL1β >19,4 pg/ml (OR=12,80; 95% CI: 2,90–56,58) and IL6 >40,1 pg/ml (OR=11,33; 95% CI: 2,46–52,15).
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